RUDY LAB
Highlights
All Publications
J Neurosci
Mechanisms of Dominant Electrophysiological Features of Four Subtypes of Layer 1 Interneurons
J. H. Meng, B. Schuman, B. Rudy, X. J. Wang
2023
Neuron
Cortical somatostatin interneuron subtypes form cell-type-specific circuits
S. J. Wu, et al.
2023
eLife
Id2 GABAergic interneurons comprise a neglected fourth major group of cortical inhibitory cells
R. Machold, et al.
2023
Annu Rev Neurosci
Neocortical Layer 1: An Elegant Solution to Top-Down and Bottom-Up Integration
B. Schuman, S. Dellal, A. Proenneke, R. Machold, B. Rudy
2021
Nat Neurosci
Sleep down state-active ID2/Nkx2.1 interneurons in the neocortex
M. Valero, et al.
2021
Neuron
Bottom-up inputs are required for establishment of top-down connectivity onto cortical layer 1 neurogliaform cells
L. A. Ibrahim, et al.
2021
Elife
Cellular birthdate predicts laminar and regional cholinergic projection topography in the forebrain
K. C. Allaway, W. Munoz, R. Tremblay, et al.
2020
Curr Opin Neurobiol
Mining the jewels of the cortex's crowning mystery
L. A. Ibrahim, B. Schuman, et al.
2020
Neuron
Dynamics of Neuronal Activity in the Cortical Column during Behavior: Both Neuron Type and Layers Matter
B. Schuman and B. Rudy
2019
J Neurosci
Four Unique Interneuron Populations Reside in Neocortical Layer 1
B. Schuman, et al.
2019
Neuron
Rbfox1 Mediates Cell-type-Specific Splicing in Cortical Interneurons
B. Wamsley, et al.
2018
J Neurosci
Diversity and Connectivity of Layer 5 Somatostatin-Expressing Interneurons in the Mouse Barrel Cortex
M. J. Nigro, Y. Hashikawa-Yamasaki, B. Rudy
2018
Nat Neurosci
Esr1+ cells in the ventromedial hypothalamus control female aggression
K. Hashikawa, et al.
2018
Proc Natl Acad Sci
Discovery of peptide ligands through docking and virtual screening at nicotinic acetylcholine receptor homology models
A. E. Leffler, et al.
2018
Science
Layer-specific modulation of neocortical dendritic inhibition during active wakefulness
W. Munoz, R. Tremblay, D. Levenstein and B. Rudy
2017
Neuron
Early Somatostatin Interneuron Connectivity Mediates the Maturation of Deep Layer Cortical Circuits
S. N. Tuncdemir, et al.
2016
Curr Biol
Drosophila SLC5A11 Mediates Hunger by Regulating K(+) Channel Activity
J. Y. Park, et al.
2016
Science
Comment on "Principles of connectivity among morphologically defined cell types in adult neocortex"
L. Barth, et al.
2016
Neuron
GABAergic Interneurons in the Neocortex: From Cellular Properties to Circuits
R. Tremblay, S. Lee and B. Rudy
2016
Nat Neurosci
A viral strategy for targeting and manipulating interneurons across vertebrate species
J. Dimidschstein, et al.
2016
Neuron
Strategies and Tools for Combinatorial Targeting of GABAergic Neurons in Mouse Cerebral Cortex
M. He, et al.
2016
Curr Opin Neurobiol
Spatiotemporal specificity in cholinergic control of neocortical function
W. Munoz and B. Rudy
2014
J Neurophysiol
The interplay of seven subthreshold conductances controls the resting membrane potential and the oscillatory behavior of thalamocortical neurons
Y. Amarillo, E. Zagha, G. Mato, B. Rudy and M. S. Nadal
2014
Nature
Cntnap4 differentially contributes to GABAergic and dopaminergic synaptic transmission
T. Karayannis, et al.
2014
Cell Rep
Channelrhodopsin-assisted patching: in vivo recording of genetically and morphologically identified neurons throughout the brain
W. Munoz, R. Tremblay and B. Rudy
2014
Nat Commun
DPP6 regulation of dendritic morphogenesis impacts hippocampal synaptic development
L. Lin, et al.
2013
Neuron
Neocortical somatostatin-expressing GABAergic interneurons disinhibit the thalamorecipient layer 4
H. Xu, H. Y. Jeong, R. Tremblay and B. Rudy
2013
Ann Neurol
CaV 2.1 ablation in cortical interneurons selectively impairs fast-spiking basket cells and causes generalized seizures
E. Rossignol, I. Kruglikov, A. M. van den Maagdenberg, B. Rudy and G. Fishell
2013
Nat Rev Neurosci
New insights into the classification and nomenclature of cortical GABAergic interneurons
J. DeFelipe, et al.
2013
Nat Neurosci
A disinhibitory circuit mediates motor integration in the somatosensory cortex
S. Lee, I. Kruglikov, Z. J. Huang, G. Fishell and B. Rudy
2013
Ann Neurol
Encephalitis and antibodies to dipeptidyl-peptidase-like protein-6, a subunit of Kv4.2 potassium channels
A. Boronat, et al.
2013
J Physiol
Dipeptidyl-peptidase-like-proteins confer high sensitivity to the scorpion toxin AmmTX3 to Kv4-mediated A-type K+ channels
J. K. Maffie, E. Dvoretskova, P. E. Bougis, M. F. Martin-Eauclaire and B. Rudy
2013
J Neurophysiol
Impaired long-range synchronization of gamma oscillations in the neocortex of a mouse lacking Kv3.2 potassium channels
M. Harvey, D. Lau, E. Civillico, B. Rudy and D. Contreras
2012
J Neurosci
Satb1 is an activity-modulated transcription factor required for the terminal differentiation and connectivity of medial ganglionic eminence-derived cortical interneurons
J. Close, et al.
2012
Neuron
DPP6 establishes the A-type K(+) current gradient critical for the regulation of dendritic excitability in CA1 hippocampal neurons
W. Sun, et al.
2011
Dev Neurobiol
Three groups of interneurons account for nearly 100% of neocortical GABAergic neurons
B. Rudy, G. Fishell, S. Lee and J. Hjerling-Leffler
2011
Annu Rev Neurosci
Mechanisms of inhibition within the telencephalon: "where the wild things are"
G. Fishell and B. Rudy
2011
Cereb Cortex
Rapid developmental maturation of neocortical FS cell intrinsic excitability
E. M. Goldberg, et al.
2011
J Neurophysiol
Dendritic Kv3.3 potassium channels in cerebellar purkinje cells regulate generation and spatial dynamics of dendritic Ca2+ spikes
E. Zagha, S. Manita, W. N. Ross and B. Rudy
2010
J Neurosci
The largest group of superficial neocortical GABAergic interneurons expresses ionotropic serotonin receptors
S. Lee, J. Hjerling-Leffler, E. Zagha, G. Fishell and B. Rudy
2010
J Neurosci
The dipeptidyl-peptidase-like protein DPP6 determines the unitary conductance of neuronal Kv4.2 channels
Y. A. Kaulin, et al.
2009
Neuroscientist
Electrogenic tuning of the axon initial segment
B. D. Clark, E. M. Goldberg and B. Rudy
2009
Neurosci Lett
A novel DPP6 isoform (DPP6-E) can account for differences between neuronal and reconstituted A-type K(+) channels
J. Maffie, T. Blenkinsop and B. Rudy
2009
J Comp Neurol
Quantitative analysis of neurons with Kv3 potassium channel subunits, Kv3.1b and Kv3.2, in macaque primary visual cortex
C. M. Constantinople, A. A. Disney, J. Maffie, B. Rudy and M. J. Hawken
2009
J Neurophysiol
Kv4 accessory protein DPPX (DPP6) is a critical regulator of membrane excitability in hippocampal CA1 pyramidal neurons
J. Kim, et al.
2008
Nat Rev Neurosci
Petilla terminology: nomenclature of features of GABAergic interneurons of the cerebral cortex
G. Petilla et al.
2008
J Physiol
Weighing the evidence for a ternary protein complex mediating A-type K+ currents in neurons
J. Maffie and B. Rudy
2008
Neuron
Perisomatic GABA release and thalamocortical integration onto neocortical excitatory cells are regulated by neuromodulators
I. Kruglikov and B. Rudy
2008
J Neurosci
Kv3.3 channels at the Purkinje cell soma are necessary for generation of the classical complex spike waveform
E. Zagha, E. J. Lang and B. Rudy
2008
J Physiol
Ternary Kv4.2 channels recapitulate voltage-dependent inactivation kinetics of A-type K+ channels in cerebellar granule neurons
Y. Amarillo, et al.
2008
Front Mol Neurosci
DPP6 Localization in Brain Supports Function as a Kv4 Channel Associated Protein
B. D. Clark, et al.
2008
Neuron
K+ channels at the axon initial segment dampen near-threshold excitability of neocortical fast-spiking GABAergic interneurons
E. M. Goldberg, et al.
2008
J Physiol
Differential regulation of action potential firing in adult murine thalamocortical neurons by Kv3.2, Kv1, and SK potassium and N-type calcium channels
M. R. Kasten, B. Rudy and M. P. Anderson
2007
J Comp Neurol
Distribution of Kv3.3 potassium channel subunits in distinct neuronal populations of mouse brain
S. Y. Chang, et al.
2007
Neuroscience
Developmental changes in the expression of calbindin and potassium-channel subunits Kv3.1b and Kv3.2 in mouse Renshaw cells
Z. M. Song, J. Hu, B. Rudy and S. J. Redman
2006
Brain Res
Differential characterization of three alternative spliced isoforms of DPPX
M. S. Nadal, Y. Amarillo, E. Vega-Saenz de Miera and B. Rudy
2006
Pharmacol Rev
International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels
G. A. Gutman, et al.
2005
J Biol Chem
DPP10 modulates Kv4-mediated A-type potassium channels
E. Zagha, et al.
2005
J Neurophysiol
Spontaneous oscillatory activity of starburst amacrine cells in the mouse retina
J. Petit-Jacques, B. Volgyi, B. Rudy and S. Bloomfield
2005
J Neurosci
Specific functions of synaptically localized potassium channels in synaptic transmission at the neocortical GABAergic fast-spiking cell synapse
E. M. Goldberg, et al.
2005
J Neurosci
A unique role for Kv3 voltage-gated potassium channels in starburst amacrine cell signaling in mouse retina
A. Ozaita, et al.
2004
Brain Res
Potassium channel subunit Kv3.2 and the water channel aquaporin-4 are selectively localized to cerebellar pinceau
M. Bobik, M. H. Ellisman, B. Rudy and M. E. Martone
2004
Neuron
The CD26-related dipeptidyl aminopeptidase-like protein DPPX is a critical component of neuronal A-type K+ channels
M. S. Nadal, et al.
2003
Pharmacol Rev
International Union of Pharmacology. XLI. Compendium of voltage-gated ion channels: potassium channels
G. A. Gutman, et al.
2003
Hippocampus
Developmental expression of potassium-channel subunit Kv3.2 within subpopulations of mouse hippocampal inhibitory interneurons
E. P. Tansey, A. Chow, B. Rudy and C. J. McBain
2002
Brain Res
Sleep EEG in mice that are deficient in the potassium channel subunit K.v.3.2
V. V. Vyazovskiy, et al.
2002
J Neurophysiol
Differential subcellular localization of the two alternatively spliced isoforms of the Kv3.1 potassium channel subunit in brain
A. Ozaita, M. E. Martone, M. H. Ellisman and B. Rudy
2002
J Physiol
Modulation of Kv3 potassium channels expressed in CHO cells by a nitric oxide-activated phosphatase
H. Moreno, E. Vega-Saenz de Miera, M. S. Nadal, Y. Amarillo and B. Rudy
2001
Proc Natl Acad Sci U S A
A role for frequenin, a Ca2+-binding protein, as a regulator of Kv4 K+-currents
T. Y. Nakamura, et al.
2001
J Neurophysiol
KT3.2 and KT3.3, two novel human two-pore K(+) channels closely related to TASK-1
E. Vega-Saenz de Miera, et al.
2001
J Neurosci
Differential expression of genes encoding subthreshold-operating voltage-gated K+ channels in brain
M. J. Saganich, E. Machado and B. Rudy
2001
J Physiol
Evidence for the presence of a novel Kv4-mediated A-type K(+) channel-modifying factor
M. S. Nadal, Y. Amarillo, E. Vega-Saenz de Miera and B. Rudy
2001
Trends Neurosci
Kv3 channels: voltage-gated K+ channels designed for high-frequency repetitive firing
B. Rudy and C. J. McBain
2001
FEBS Lett
Different effects of the Ca(2+)-binding protein, KChIP1, on two Kv4 subfamily members, Kv4.1 and Kv4.2
T. Y. Nakamura, et al.
2001
J Neurosci
Impaired fast-spiking, suppressed cortical inhibition, and increased susceptibility to seizures in mice lacking Kv3.2 K+ channel proteins
D. Lau, et al.
2000
Nat Neurosci
H2 histamine receptor-phosphorylation of Kv3.2 modulates interneuron fast spiking
M. Atzori, et al.
2000
J Biol Chem
The effects of Shaker beta-subunits on the human lymphocyte K+ channel Kv1.3
T. McCormack, et al.
1999
Ann N Y Acad Sci
Contributions of Kv3 channels to neuronal excitability
B. Rudy, A. et al.
1999
Ann N Y Acad Sci
Molecular diversity of K+ channels
W. A. Coetzee, et al.
1999
J Neurosci
Cloning of components of a novel subthreshold-activating K(+) channel with a unique pattern of expression in the cerebral cortex
M. J. Saganich, et al.
1999
Ann N Y Acad Sci
The role of Kir2.1 in the genesis of native cardiac inward-rectifier K+ currents during pre- and postnatal development
T. Y. Nakamura, K. Lee, M. Artman, B. Rudy and W. A. Coetzee
1999
Genomics
Chromosomal mapping of the potassium channel genes Kcnq2 and Kcnq3 in mouse
T. McCormack, B. Rudy and M. F. Seldin
1999
FEBS Lett
Identification and cloning of TWIK-originated similarity sequence (TOSS): a novel human 2-pore K+ channel principal subunit
D. J. Pountney, et al.
1999
J Neurophysiol
Function of specific K(+) channels in sustained high-frequency firing of fast-spiking neocortical interneurons
A. Erisir, D. Lau, B. Rudy and C. S. Leonard
1999
J Neurophysiol
Kv3.1-Kv3.2 channels underlie a high-voltage-activating component of the delayed rectifier K+ current in projecting neurons from the globus pallidus
R. Hernandez-Pineda, et al.
1999
J Neurosci
K(+) channel expression distinguishes subpopulations of parvalbumin- and somatostatin-containing neocortical interneurons
A. Chow, et al.
1999
J Neurophysiol
FGF-2 potentiates Ca(2+)-dependent inactivation of NMDA receptor currents in hippocampal neurons
A. L. Boxer, H. Moreno, B. Rudy and E. B. Ziff
1999
Ann N Y Acad Sci
Molecular diversity of ion channels and cell function
B. Rudy
1999
Am J Physiol
Inhibition of rat ventricular IK1 with antisense oligonucleotides targeted to Kir2.1 mRNA
T. Y. Nakamura, M. Artman, B. Rudy and W. A. Coetzee
1998
J Neurophysiol
Differential expression of Kv4 K+ channel subunits mediating subthreshold transient K+ (A-type) currents in rat brain
P. Serodio and B. Rudy
1998
Proc Natl Acad Sci U S A
beta subunits influence the biophysical and pharmacological differences between P- and Q-type calcium currents expressed in a mammalian cell line
H. Moreno, B. Rudy and R. Llinas
1997
Am J Physiol
Modulation of Kv4 channels, key components of rat ventricular transient outward K+ current, by PKC
T. Y. Nakamura, W. A. Coetzee, E. Vega-Saenz De Miera, M. Artman and B. Rudy
1997
J Membr Biol
K+ channel subunit isoforms with divergent carboxy-terminal sequences carry distinct membrane targeting signals
A. Ponce, et al.
1997
Proc Natl Acad Sci U S A
Molecular characterization of the sodium channel subunits expressed in mammalian cerebellar Purkinje cells
E. C. Vega-Saenz de Miera, B. Rudy, M. Sugimori and R. Llinas
1997
Brain Res
Subcellular localization of the K+ channel subunit Kv3.1b in selected rat CNS neurons
C. Sekirnjak, et al.
1997
J Neurosci
G-protein-gated inward rectifier K+ channel proteins (GIRK1) are present in the soma and dendrites as well as in nerve terminals of specific neurons in the brain
A. Ponce, et al.
1996
J Neurophysiol
Cloning of a novel component of A-type K+ channels operating at subthreshold potentials with unique expression in heart and brain
P. Serodio, E. Vega-Saenz de Miera and B. Rudy
1996
J Neurosci
Developmental expression and functional characterization of the potassium-channel subunit Kv3.1b in parvalbumin-containing interneurons of the rat hippocampus
J. Du, L. Zhang, M. Weiser, B. Rudy and C. J. McBain
1996
Recept Signal Transduct
Heterologous desensitization of the human endothelin A and neurokinin A receptors in Xenopus laevis oocytes
C. R. Cyr, L. A. Devi, B. Rudy and R. M. Kris
1996
Biochemistry
Specific interaction of (R)-3-hydroxybutyrate dehydrogenase with membrane phosphatidylcholine as studied by ESR spectroscopy in oriented phospholipid multibilayers: coenzyme binding enhances the interaction with phosphatidylcholine
K. Klein, B. Rudy, J. O. McIntyre, S. Fleischer and W. E. Trommer
1996