Highlights

2021 SchumanB AnnuRevNeuro-f1_edited_edited.jpg
Neocortical Layer 1: An Elegant Solution to Top-Down and Bottom-Up Integration
B Schuman, S Dellal, A Proenneke, R Machold, B Rudy
Annual Review of Neuroscience. 2021 Jul 8; 44: 221-252.
Bernardo Rudy Lab
Four Unique Interneuron Populations Reside in Neocortical Layer 1
B Schuman, RP Machold, Y Hashikawa, J Fuzik, GJ Fishell, B Rudy
Journal of Neuroscience. 2019 Jan 2; 39(1): 125-139.
Bernardo Rudy Lab
Diversity and Connectivity of Layer 5 Somatostatin-Expressing Interneurons in the Mouse Barrel Cortex
MJ Nigro, Y Hashikawa, B Rudy
Journal of Neuroscience. 2018 Feb 14; 38(7): 1622-1633.
Bernardo Rudy Lab
Layer-specific modulation of neocortical dendritic inhibition during active wakefulness
W Munoz, R Tremblay, D Levenstein, B Rudy
Science. 2017 Mar 3; 355(6328): 954-959.
Bernardo Rudy Lab
Strategies and Tools for Combinatorial Targeting of GABAergic Neurons in Mouse Cerebral Cortex
M He, J Tucciarone, S Lee, MJ Nigro, Y Kim, JM Levine, SM Kelly, I Kruglikov, P Wu, Y Chen, L Gong, Y Hou, P Osten, B Rudy, ZJ Huang.
Neuron. 2016 Sep 21; 91(6): 1228-1243.
Bernardo Rudy Lab
GABAergic Interneurons in the Neocortex: From Cellular Properties to Circuits
R Tremblay, S Lee, B Rudy.
Neuron. 2016 Jul 20; 91(2): 260-92.
Bernardo Rudy Lab
Channelrhodopsin-assisted patching: in vivo recording of genetically and morphologically identified neurons throughout the brain
W Munoz, R Tremblay, B Rudy.
Cell Rep. 2014 Dec 24; 9(6): 2304-16.
Bernardo Rudy Lab
Spatiotemporal specificity in cholinergic control of neocortical function
W Munoz and B Rudy.
Curr Opin Neurobiol. 2014 Jun; 26: 149-60.
Bernardo Rudy Lab
A disinhibitory circuit mediates motor integration in the somatosensory cortex
S Lee, I Kruglikov, ZJ Huang, G Fishell, B Rudy.
Nat Neurosci. 2013 Nov; 16(11): 1662-70.
Bernardo Rudy Lab
Neocortical somatostatin-expressing GABAergic interneurons disinhibit the thalamorecipient layer 4
H Xu, HY Jeong, R Tremblay, B Rudy.
Neuron. 2013 Jan 9; 77(1): 155-67.
Bernardo Rudy Lab
Mechanisms of inhibition within the telencephalon: "where the wild things are"
G Fishell and B Rudy.
Annu Rev Neurosci. 2011; 34: 535-67.
Bernardo Rudy Lab
The largest group of superficial neocortical GABAergic interneurons expresses ionotropic serotonin receptors
S Lee, J Hjerling-Leffler, E Zagha, G Fishell, B Rudy.
J Neurosci. 2010 Dec 15 ;30(50): 16796-808.

All Publications

Annu Rev Neurosci

Neocortical Layer 1: An Elegant Solution to Top-Down and Bottom-Up Integration

B. Schuman, S. Dellal, A. Proenneke, R. Machold, B. Rudy

2021

Nat Neurosci

Sleep down state-active ID2/Nkx2.1 interneurons in the neocortex

M. Valero, et al.

2021

Neuron

Bottom-up inputs are required for establishment of top-down connectivity onto cortical layer 1 neurogliaform cells

L. A. Ibrahim, et al.

2021

Elife

Cellular birthdate predicts laminar and regional cholinergic projection topography in the forebrain

K. C. Allaway, W. Munoz, R. Tremblay, et al.

2020

Curr Opin Neurobiol

Mining the jewels of the cortex's crowning mystery

L. A. Ibrahim, B. Schuman, et al.

2020

J Neurosci

Four Unique Interneuron Populations Reside in Neocortical Layer 1

B. Schuman, et al.

2019

Neuron

Dynamics of Neuronal Activity in the Cortical Column during Behavior: Both Neuron Type and Layers Matter

B. Schuman and B. Rudy

2019

Proc Natl Acad Sci

Discovery of peptide ligands through docking and virtual screening at nicotinic acetylcholine receptor homology models

A. E. Leffler, et al.

2018

Nat Neurosci

Esr1+ cells in the ventromedial hypothalamus control female aggression

K. Hashikawa, et al.

2018

J Neurosci

Diversity and Connectivity of Layer 5 Somatostatin-Expressing Interneurons in the Mouse Barrel Cortex

M. J. Nigro, Y. Hashikawa-Yamasaki, B. Rudy

2018

Neuron

Rbfox1 Mediates Cell-type-Specific Splicing in Cortical Interneurons

B. Wamsley, et al.

2018

Science

Layer-specific modulation of neocortical dendritic inhibition during active wakefulness

W. Munoz, R. Tremblay, D. Levenstein and B. Rudy

2017

Nat Neurosci

A viral strategy for targeting and manipulating interneurons across vertebrate species

J. Dimidschstein, et al.

2016

Curr Biol

Drosophila SLC5A11 Mediates Hunger by Regulating K(+) Channel Activity

J. Y. Park, et al.

2016

Science

Comment on "Principles of connectivity among morphologically defined cell types in adult neocortex"

L. Barth, et al.

2016

Neuron

Early Somatostatin Interneuron Connectivity Mediates the Maturation of Deep Layer Cortical Circuits

S. N. Tuncdemir, et al.

2016

Neuron

GABAergic Interneurons in the Neocortex: From Cellular Properties to Circuits

R. Tremblay, S. Lee and B. Rudy

2016

Neuron

Strategies and Tools for Combinatorial Targeting of GABAergic Neurons in Mouse Cerebral Cortex

M. He, et al.

2016

J Neurophysiol

The interplay of seven subthreshold conductances controls the resting membrane potential and the oscillatory behavior of thalamocortical neurons

Y. Amarillo, E. Zagha, G. Mato, B. Rudy and M. S. Nadal

2014

Curr Opin Neurobiol

Spatiotemporal specificity in cholinergic control of neocortical function

W. Munoz and B. Rudy

2014

Cell Rep

Channelrhodopsin-assisted patching: in vivo recording of genetically and morphologically identified neurons throughout the brain

W. Munoz, R. Tremblay and B. Rudy

2014

Nature

Cntnap4 differentially contributes to GABAergic and dopaminergic synaptic transmission

T. Karayannis, et al.

2014

Nat Rev Neurosci

New insights into the classification and nomenclature of cortical GABAergic interneurons

J. DeFelipe, et al.

2013

Nat Commun

DPP6 regulation of dendritic morphogenesis impacts hippocampal synaptic development

L. Lin, et al.

2013

Ann Neurol

CaV 2.1 ablation in cortical interneurons selectively impairs fast-spiking basket cells and causes generalized seizures

E. Rossignol, I. Kruglikov, A. M. van den Maagdenberg, B. Rudy and G. Fishell

2013

Nat Neurosci

A disinhibitory circuit mediates motor integration in the somatosensory cortex

S. Lee, I. Kruglikov, Z. J. Huang, G. Fishell and B. Rudy

2013

Ann Neurol

Encephalitis and antibodies to dipeptidyl-peptidase-like protein-6, a subunit of Kv4.2 potassium channels

A. Boronat, et al.

2013

Neuron

Neocortical somatostatin-expressing GABAergic interneurons disinhibit the thalamorecipient layer 4

H. Xu, H. Y. Jeong, R. Tremblay and B. Rudy

2013

J Physiol

Dipeptidyl-peptidase-like-proteins confer high sensitivity to the scorpion toxin AmmTX3 to Kv4-mediated A-type K+ channels

J. K. Maffie, E. Dvoretskova, P. E. Bougis, M. F. Martin-Eauclaire and B. Rudy

2013

J Neurosci

Satb1 is an activity-modulated transcription factor required for the terminal differentiation and connectivity of medial ganglionic eminence-derived cortical interneurons

J. Close, et al.

2012

J Neurophysiol

Impaired long-range synchronization of gamma oscillations in the neocortex of a mouse lacking Kv3.2 potassium channels

M. Harvey, D. Lau, E. Civillico, B. Rudy and D. Contreras

2012

Cereb Cortex

Rapid developmental maturation of neocortical FS cell intrinsic excitability

E. M. Goldberg, et al.

2011

Annu Rev Neurosci

Mechanisms of inhibition within the telencephalon: "where the wild things are"

G. Fishell and B. Rudy

2011

Neuron

DPP6 establishes the A-type K(+) current gradient critical for the regulation of dendritic excitability in CA1 hippocampal neurons

W. Sun, et al.

2011

Dev Neurobiol

Three groups of interneurons account for nearly 100% of neocortical GABAergic neurons

B. Rudy, G. Fishell, S. Lee and J. Hjerling-Leffler

2011

J Neurophysiol

Dendritic Kv3.3 potassium channels in cerebellar purkinje cells regulate generation and spatial dynamics of dendritic Ca2+ spikes

E. Zagha, S. Manita, W. N. Ross and B. Rudy

2010

J Neurosci

The largest group of superficial neocortical GABAergic interneurons expresses ionotropic serotonin receptors

S. Lee, J. Hjerling-Leffler, E. Zagha, G. Fishell and B. Rudy

2010

J Comp Neurol

Quantitative analysis of neurons with Kv3 potassium channel subunits, Kv3.1b and Kv3.2, in macaque primary visual cortex

C. M. Constantinople, A. A. Disney, J. Maffie, B. Rudy and M. J. Hawken

2009

J Neurosci

The dipeptidyl-peptidase-like protein DPP6 determines the unitary conductance of neuronal Kv4.2 channels

Y. A. Kaulin, et al.

2009

Neuroscientist

Electrogenic tuning of the axon initial segment

B. D. Clark, E. M. Goldberg and B. Rudy

2009

Neurosci Lett

A novel DPP6 isoform (DPP6-E) can account for differences between neuronal and reconstituted A-type K(+) channels

J. Maffie, T. Blenkinsop and B. Rudy

2009

Neuron

K+ channels at the axon initial segment dampen near-threshold excitability of neocortical fast-spiking GABAergic interneurons

E. M. Goldberg, et al.

2008

J Neurophysiol

Kv4 accessory protein DPPX (DPP6) is a critical regulator of membrane excitability in hippocampal CA1 pyramidal neurons

J. Kim, et al.

2008

Front Mol Neurosci

DPP6 Localization in Brain Supports Function as a Kv4 Channel Associated Protein

B. D. Clark, et al.

2008

Nat Rev Neurosci

Petilla terminology: nomenclature of features of GABAergic interneurons of the cerebral cortex

G. Petilla et al.

2008

J Neurosci

Kv3.3 channels at the Purkinje cell soma are necessary for generation of the classical complex spike waveform

E. Zagha, E. J. Lang and B. Rudy

2008

J Physiol

Weighing the evidence for a ternary protein complex mediating A-type K+ currents in neurons

J. Maffie and B. Rudy

2008

Neuron

Perisomatic GABA release and thalamocortical integration onto neocortical excitatory cells are regulated by neuromodulators

I. Kruglikov and B. Rudy

2008

J Physiol

Ternary Kv4.2 channels recapitulate voltage-dependent inactivation kinetics of A-type K+ channels in cerebellar granule neurons

Y. Amarillo, et al.

2008

J Comp Neurol

Distribution of Kv3.3 potassium channel subunits in distinct neuronal populations of mouse brain

S. Y. Chang, et al.

2007

J Physiol

Differential regulation of action potential firing in adult murine thalamocortical neurons by Kv3.2, Kv1, and SK potassium and N-type calcium channels

M. R. Kasten, B. Rudy and M. P. Anderson

2007

Neuroscience

Developmental changes in the expression of calbindin and potassium-channel subunits Kv3.1b and Kv3.2 in mouse Renshaw cells

Z. M. Song, J. Hu, B. Rudy and S. J. Redman

2006

Brain Res

Differential characterization of three alternative spliced isoforms of DPPX

M. S. Nadal, Y. Amarillo, E. Vega-Saenz de Miera and B. Rudy

2006

J Neurosci

Specific functions of synaptically localized potassium channels in synaptic transmission at the neocortical GABAergic fast-spiking cell synapse

E. M. Goldberg, et al.

2005

J Neurophysiol

Spontaneous oscillatory activity of starburst amacrine cells in the mouse retina

J. Petit-Jacques, B. Volgyi, B. Rudy and S. Bloomfield

2005

Pharmacol Rev

International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels

G. A. Gutman, et al.

2005

J Biol Chem

DPP10 modulates Kv4-mediated A-type potassium channels

E. Zagha, et al.

2005

J Neurosci

A unique role for Kv3 voltage-gated potassium channels in starburst amacrine cell signaling in mouse retina

A. Ozaita, et al.

2004

Brain Res

Potassium channel subunit Kv3.2 and the water channel aquaporin-4 are selectively localized to cerebellar pinceau

M. Bobik, M. H. Ellisman, B. Rudy and M. E. Martone

2004

Pharmacol Rev

International Union of Pharmacology. XLI. Compendium of voltage-gated ion channels: potassium channels

G. A. Gutman, et al.

2003

Neuron

The CD26-related dipeptidyl aminopeptidase-like protein DPPX is a critical component of neuronal A-type K+ channels

M. S. Nadal, et al.

2003

Hippocampus

Developmental expression of potassium-channel subunit Kv3.2 within subpopulations of mouse hippocampal inhibitory interneurons

E. P. Tansey, A. Chow, B. Rudy and C. J. McBain

2002

J Neurophysiol

Differential subcellular localization of the two alternatively spliced isoforms of the Kv3.1 potassium channel subunit in brain

A. Ozaita, M. E. Martone, M. H. Ellisman and B. Rudy

2002

Brain Res

Sleep EEG in mice that are deficient in the potassium channel subunit K.v.3.2

V. V. Vyazovskiy, et al.

2002

J Neurosci

Differential expression of genes encoding subthreshold-operating voltage-gated K+ channels in brain

M. J. Saganich, E. Machado and B. Rudy

2001

Proc Natl Acad Sci U S A

A role for frequenin, a Ca2+-binding protein, as a regulator of Kv4 K+-currents

T. Y. Nakamura, et al.

2001

J Neurophysiol

KT3.2 and KT3.3, two novel human two-pore K(+) channels closely related to TASK-1

E. Vega-Saenz de Miera, et al.

2001

J Physiol

Modulation of Kv3 potassium channels expressed in CHO cells by a nitric oxide-activated phosphatase

H. Moreno, E. Vega-Saenz de Miera, M. S. Nadal, Y. Amarillo and B. Rudy

2001

J Physiol

Evidence for the presence of a novel Kv4-mediated A-type K(+) channel-modifying factor

M. S. Nadal, Y. Amarillo, E. Vega-Saenz de Miera and B. Rudy

2001

FEBS Lett

Different effects of the Ca(2+)-binding protein, KChIP1, on two Kv4 subfamily members, Kv4.1 and Kv4.2

T. Y. Nakamura, et al.

2001

Trends Neurosci

Kv3 channels: voltage-gated K+ channels designed for high-frequency repetitive firing

B. Rudy and C. J. McBain

2001

J Neurosci

Impaired fast-spiking, suppressed cortical inhibition, and increased susceptibility to seizures in mice lacking Kv3.2 K+ channel proteins

D. Lau, et al.

2000

Nat Neurosci

H2 histamine receptor-phosphorylation of Kv3.2 modulates interneuron fast spiking

M. Atzori, et al.

2000

J Neurosci

K(+) channel expression distinguishes subpopulations of parvalbumin- and somatostatin-containing neocortical interneurons

A. Chow, et al.

1999

FEBS Lett

Identification and cloning of TWIK-originated similarity sequence (TOSS): a novel human 2-pore K+ channel principal subunit

D. J. Pountney, et al.

1999

Genomics

Chromosomal mapping of the potassium channel genes Kcnq2 and Kcnq3 in mouse

T. McCormack, B. Rudy and M. F. Seldin

1999

Ann N Y Acad Sci

The role of Kir2.1 in the genesis of native cardiac inward-rectifier K+ currents during pre- and postnatal development

T. Y. Nakamura, K. Lee, M. Artman, B. Rudy and W. A. Coetzee

1999

J Neurophysiol

FGF-2 potentiates Ca(2+)-dependent inactivation of NMDA receptor currents in hippocampal neurons

A. L. Boxer, H. Moreno, B. Rudy and E. B. Ziff

1999

Ann N Y Acad Sci

Molecular diversity of ion channels and cell function

B. Rudy

1999

J Neurophysiol

Function of specific K(+) channels in sustained high-frequency firing of fast-spiking neocortical interneurons

A. Erisir, D. Lau, B. Rudy and C. S. Leonard

1999

Ann N Y Acad Sci

Molecular diversity of K+ channels

W. A. Coetzee, et al.

1999

J Biol Chem

The effects of Shaker beta-subunits on the human lymphocyte K+ channel Kv1.3

T. McCormack, et al.

1999

J Neurophysiol

Kv3.1-Kv3.2 channels underlie a high-voltage-activating component of the delayed rectifier K+ current in projecting neurons from the globus pallidus

R. Hernandez-Pineda, et al.

1999

Ann N Y Acad Sci

Contributions of Kv3 channels to neuronal excitability

B. Rudy, A. et al.

1999

J Neurosci

Cloning of components of a novel subthreshold-activating K(+) channel with a unique pattern of expression in the cerebral cortex

M. J. Saganich, et al.

1999

Am J Physiol

Inhibition of rat ventricular IK1 with antisense oligonucleotides targeted to Kir2.1 mRNA

T. Y. Nakamura, M. Artman, B. Rudy and W. A. Coetzee

1998

J Neurophysiol

Differential expression of Kv4 K+ channel subunits mediating subthreshold transient K+ (A-type) currents in rat brain

P. Serodio and B. Rudy

1998

Brain Res

Subcellular localization of the K+ channel subunit Kv3.1b in selected rat CNS neurons

C. Sekirnjak, et al.

1997

Am J Physiol

Modulation of Kv4 channels, key components of rat ventricular transient outward K+ current, by PKC

T. Y. Nakamura, W. A. Coetzee, E. Vega-Saenz De Miera, M. Artman and B. Rudy

1997

J Membr Biol

K+ channel subunit isoforms with divergent carboxy-terminal sequences carry distinct membrane targeting signals

A. Ponce, et al.

1997

Proc Natl Acad Sci U S A

beta subunits influence the biophysical and pharmacological differences between P- and Q-type calcium currents expressed in a mammalian cell line

H. Moreno, B. Rudy and R. Llinas

1997

Proc Natl Acad Sci U S A

Molecular characterization of the sodium channel subunits expressed in mammalian cerebellar Purkinje cells

E. C. Vega-Saenz de Miera, B. Rudy, M. Sugimori and R. Llinas

1997

J Neurosci

Developmental expression and functional characterization of the potassium-channel subunit Kv3.1b in parvalbumin-containing interneurons of the rat hippocampus

J. Du, L. Zhang, M. Weiser, B. Rudy and C. J. McBain

1996

Biochemistry

Specific interaction of (R)-3-hydroxybutyrate dehydrogenase with membrane phosphatidylcholine as studied by ESR spectroscopy in oriented phospholipid multibilayers: coenzyme binding enhances the interaction with phosphatidylcholine

K. Klein, B. Rudy, J. O. McIntyre, S. Fleischer and W. E. Trommer

1996

J Neurosci

G-protein-gated inward rectifier K+ channel proteins (GIRK1) are present in the soma and dendrites as well as in nerve terminals of specific neurons in the brain

A. Ponce, et al.

1996

Recept Signal Transduct

Heterologous desensitization of the human endothelin A and neurokinin A receptors in Xenopus laevis oocytes

C. R. Cyr, L. A. Devi, B. Rudy and R. M. Kris

1996

J Neurophysiol

Cloning of a novel component of A-type K+ channels operating at subthreshold potentials with unique expression in heart and brain

P. Serodio, E. Vega-Saenz de Miera and B. Rudy

1996

Proc Natl Acad Sci U S A

NADPH-oxidase and a hydrogen peroxide-sensitive K+ channel may function as an oxygen sensor complex in airway chemoreceptors and small cell lung carcinoma cell lines

D. Wang, et al.

1996

Nature

Protein tyrosine kinase PYK2 involved in Ca(2+)-induced regulation of ion channel and MAP kinase functions

S. Lev, et al.

1995

J Neurosci

Thalamocortical projections have a K+ channel that is phosphorylated and modulated by cAMP-dependent protein kinase

H. Moreno, et al.

1995